Effects of perinatal disease activity on offspring's growth in patients with systemic lupus erythematosus

Introduction To systematically analyze the associations of perinatal disease activity with adverse outcomes Chinese patients systemic lupus erythematosus (SLE) and their offspring. Material methods Data prenatal SLE healthy pregnant woman admitted to our hospital during October 2001 January 2018 were retrospectively collected, status offspring was followed-up in March 2020. Disease evaluated by index 2000 (SLEDAI-2k), those scores > 6 defined as having active disease. Results Totally 198 deliveries 194 199 women documented. Maternal fetal occurred 74 (37.4%) 90 (45.5%) respectively, which significantly higher than subjects. Among patients, group had rates gestational hypertension (p<0.001), preeclampsia/eclampsia low birth weight premature (p<0.001) growth restriction (FGR) (p<0.01) inactive group. Multivariate logistic analysis revealed that renal associated (OR 4.43, p<0.001), preeclampsia/ eclampsia 9.14, 2.24, p<0.05) 4.20, p<0.001). Compared general population, relatively high eczema (50/142 35.2%) congenital heart (6/142 4.2%), irrelevant activity, but related specific antibodies. Conclusions For women, is a variety pregnancy outcomes. However, maternal does not seem affect